I have the Steam version of TES4 GOTY Deluxe installed into X86 Program Files, have OBSE installed and a couple dozen mods as well. I've added retextures, body types, character overhauls, magic overhauls, etc.....and I've just completed the mages' guild quests and some of the main quest all without a single hitch of any sort. It's very stable and has had no weird bugs/glitches and not a single freeze or crash (all while the XBox version would've driven me nuts by now LOL).