After hours of reserach I got it to work. I think the reason why it didn't work was because I installed Windows 10 directly over my Windows 7 setup. Because I make full backups of all of my installments it was not a big deal to do some experiments. What I noticed was after a fresh install of WIndows 10, NVidia drivers, DirectX, VCRedist, Dotnet, Steam (did I forget something?) Skyrim + ENBs d3d9.dll workes fine. So I restored my Windows 10 installation and installed the following: -DirectX End-User Runtimes (June 2010) DL -DirectX End-User Runtimes (August 2009) DL -DirectX Software Development Kit DL -Microsoft Visual C++ 2010 Redistributable Package (x86) from C:\Steam\steamapps\common\skyrim\VCRedist\vcredist_x86.exe Yes, I'm running Windows 10 x64 but installed the x86 package. After that I did a fresh install of NMM 0.63.14. Now it works. The Launcher still crashes with d3d9.dll present but starting SKSE via NMM works fine. No RUn As Admin and no Compatibility Mode on any file. Maybe this is helpful.