My Skyrim is heavily modded and I'm sure that there are some script residuals in the saved game files, still it actually runs quite stable and I'm happily playing along. However, during the Dawnguard campagne I have been transformed into a vampire and that's the moment when the problems start. The game is still running pretty stable, but there is heavy script lag. You notice that the game takes seconds to react on many things, like application of spell effects or the result of the action key etc. Also the MCM menus are often not displayed correctly and the Extensible Framework Wheel is sometimes empty. It doesn't matter whether I'm infected and become a "normal" vampire or i'm transformed by Lord Harkon into a Vampire Lord. The effect is the same. I tried to uninstall many mods I'm using (following the uninstall procedure if present), including the vampire mods (Vampiric Thirst, Dynamic Vampire Appearance, Magic Beasts), all the animation mods (FNIS including SoS and SexLab and all associated mods, Dual Sheath Redux, Realistic Ragdoll and YY Anim Replacer) and the new "Immersive Fist Person View". Other mods like Skyrim Redone can't really be uninstalled or are just for optics and I can't imagine that they would have an effect only when I'm a vampire. None of this made any difference. The papyrus log doesn't show anything special, with the exception of error messages created by the stuck "MannequinActivatorSCRIPT" which I can't purge out of the game file. But that is most likely not the cause for the problem, because I've gotten those messages for months now and they never had any noticeable impact on the game. Has anyone experienced something similar? Is there a way to do a profiling on papyrus and figure out which script is causing these lags? Here's my list of mods: