I know for me, I don't really have a specific way to play the game like what has been mentioned here. The weapons and my inventory and companions all depend upon the type of character I'm playing. I have all around good guys who fight fair and try to keep all their companions alive, I have evil characters who kill and toy with every character they come across, and I have things in between. The one thing I would like to mention, though, is no matter which character I'm playing, or if I'm using a friend's computer or whatever, I always change the key for VATS to Q.