I notice you have Streamline 2.1.esp. For one thing, that is a very old version. I suggest you use 3.0 for more stability when saving than 3.1, but I in fact do not use Streamline any longer for auto-saves because it was Streamline that had been causing me to CTD on save. Yes, and I think that's also true of 3.0 unfortunately. I now use it solely for FPS management. For saving I suggest this mod: Auto-save and time Simply edit its .INI file to disable whatever other features you don't need or want. I use Streamline for FPS management. No matter how you choose to use Streamline, it should be at the very end of your load order. I also very strongly suggest you download BOSS and use that to automatically sort your load order.