I have the same problem, but I have a Fury X card and have been running on the ultra setting at 2560x1600 for many hours. When saving, I only get a single *.ess.tmp 0 kb file, and no .skse cosave. Loaded earlier save and another CTD upon trying to save it. I also tried re-installing skse64 and verified the game files, cleaning them w/SSEEdit. This is a real pain. Lvl 91, 800+ saves, only the last two manual saves kept in the savegame folder after every game session. I have the skse logs, but need help on posting them. The skse.log does show a save, #896, that I had deleted after the first crash. The loader and steam loader logs look ok to me, but I don't know enough to notice much. skse64_loader log: skse64 loader 02000060 01D3C32B3DDCD696 6.1 (7601) config path = C:\Games\Bethesda Softworks\Skyrim\SteamApps\common\Skyrim Special Edition\Data\SKSE\skse.ini procPath = C:\Games\Bethesda Softworks\Skyrim\SteamApps\common\Skyrim Special Edition\\SkyrimSE.exe launching: SkyrimSE.exe (C:\Games\Bethesda Softworks\Skyrim\SteamApps\common\Skyrim Special Edition\\SkyrimSE.exe) dwSignature = FEEF04BD dwStrucVersion = 00010000 dwFileVersionMS = 00010000 dwFileVersionLS = 00000000 dwProductVersionMS = 00010000 dwProductVersionLS = 00000000 dwFileFlagsMask = 00000017 dwFileFlags = 00000000 dwFileOS = 00000004 dwFileType = 00000001 dwFileSubtype = 00000000 dwFileDateMS = 00000000 dwFileDateLS = 00000000 productVersionStr = 1.5.23.0 version = 0001000500170000 product name = TESV: Skyrim steam exe dll = C:\Games\Bethesda Softworks\Skyrim\SteamApps\common\Skyrim Special Edition\\skse64_1_5_23.dll main thread id = 516 hookBase = 0000000000060000 loadLibraryAAddr = 00000000770E6510 hook thread complete launching steam loader log: skse64 loader 02000060 (steam) 01D3C32B3DDF95C1 6.1 (7601) loader base addr = 000007FEFB160000 exe base addr = 000000013FFA0000 found iat at 00000001414C2898 original thunk 000007FEFB9D1000 patched iat HookMain: thread = 516 retaddr = 0000000141301DE9 runtimePath = C:\Games\Bethesda Softworks\Skyrim\SteamApps\common\Skyrim Special Edition\SkyrimSE.exe dwSignature = FEEF04BD dwStrucVersion = 00010000 dwFileVersionMS = 00010000 dwFileVersionLS = 00000000 dwProductVersionMS = 00010000 dwProductVersionLS = 00000000 dwFileFlagsMask = 00000017 dwFileFlags = 00000000 dwFileOS = 00000004 dwFileType = 00000001 dwFileSubtype = 00000000 dwFileDateMS = 00000000 dwFileDateLS = 00000000 productVersionStr = 1.5.23.0 version = 0001000500170000 product name = TESV: Skyrim steam exe dll = C:\Games\Bethesda Softworks\Skyrim\SteamApps\common\Skyrim Special Edition\\skse64_1_5_23.dll