Is the game crashing before it even starts up, crashing on game load, or crashing during gameplay..?
Probably TrueHUD causing the crashes... There were literally hundreds of reports and posts since last winter's game update (late autumn too if you want to get technical), of the various HUD mods like TrueHUD and MoreHUD causing crashes (or people having these mods in their list and not realizing it was these ones causing the crash). Commonly cause the game to crash on start up.
Open Cities..? Nope, nope, nope, learn to do without that. Get yourself an SSD hard drive if possible, then loading screens time aren't a problem (if that's the reason you have that mod in the first place)
I liked Animated Ships, but it was causing consistent crashes in Lake Honrich near Riften so unfortunately I had to get rid of it. Might have been because of incompatibility with at least 1 other mod I use (Underwater Treasures AIO), but there weren't consistent crashes going on in the far northwest between Solitude and Castle Volkihar where there's way more Underwater Treasures additions.